TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.
Product Specifications
CAS Number
[1035555-63-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TAK-733.html
Purity
99.79
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO
Molecular Formula
C17H15F2IN4O4
Molecular Weight
504.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Dong Q, et al. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21 (5) :1315-9.|[2]Micel LN, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14 (2) :317-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MEK
Available Sizes
Curated Selection
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