AChE/BChE-IN-19

AChE/BChE-IN-19 (Compound 12) is a nicotinic hydrazide derivative. AChE/BChE-IN-19 is a inhibitor of AChE (IC50 = 21.45 nM) and BChE (IC50 =18.42 nM) . AChE/BChE-IN-19 can be used in Alzheimer's disease research[1].

Product Specifications

CAS Number

[3036136-22-5]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-bche-in-19.html

Solubility

10 mM in DMSO

Smiles

O=C(N/N=C/C1=C(C=CC=C2)C2=CC=C1OC(C3=CC=C(N(C)C)C=C3)=O)C4=CN=CC=C4

Molecular Formula

C26H22N4O3

Molecular Weight

438.48

References & Citations

[1]Resiţ Çakmak, et al. Synthesis of Novel Hydrazide−Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II. ACS Omega. 2024, 9, 18, 20030–20041