KS-133 (TFA)
KS-133 TFA is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 TFA plays an important role in schizophrenia research[1].
Product Specifications
UNSPSC
12352209
Target
PACAP Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ks-133-tfa.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N(CCC2)[C@]2([H])C3=O)=O)CC(C)C)=O)CC(C=C4)=CC=C4O)=O)[C@@](CCC5)([H])N5C([C@H](CSSC[C@@](NC([C@@H](NC([C@@H](NC6=O)CC(C=C7)=CC=C7O)=O)CC(C)C)=O)([H])C(N[C@@H](CC(NCCCC[C@]6([H])N3)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)[C@@H](C)CC)=O)=O)=O)NC(C)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C77H112F3N15O19S2
Molecular Weight
1672.93
References & Citations
[1]Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![GNA14 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3E8]](https://cdn.genprice.uk/products/937/6868c40b994c49e6dc4056d9/imageurl/ta812023bm.webp)
TA812023BM 100 µL
GNA14 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3E8]
Sign In for Pricing
View Details 
