KS-133 (TFA)
KS-133 TFA is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 TFA plays an important role in schizophrenia research[1].
Product Specifications
UNSPSC
12352209
Target
PACAP Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ks-133-tfa.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N(CCC2)[C@]2([H])C3=O)=O)CC(C)C)=O)CC(C=C4)=CC=C4O)=O)[C@@](CCC5)([H])N5C([C@H](CSSC[C@@](NC([C@@H](NC([C@@H](NC6=O)CC(C=C7)=CC=C7O)=O)CC(C)C)=O)([H])C(N[C@@H](CC(NCCCC[C@]6([H])N3)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)[C@@H](C)CC)=O)=O)=O)NC(C)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C77H112F3N15O19S2
Molecular Weight
1672.93
References & Citations
[1]Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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