NOD1-RIPK2-IN-1

NOD1-RIPK2-IN-1 (Compound 37) is a NOD1-RIPK2 signaling pathway inhibitor with IC50 values of 42 nM and 1.52 nM for NOD1 and RIPK2, respectively. NOD1-RIPK2-IN-1 reduces the secretion of the pro-inflammatory cytokine IL-8 and can be used in the research of inflammation and immune-related diseases[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NOD-like Receptor (NLR) ; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nod1-ripk2-in-1.html

Smiles

COC1=CC2=C(N=CN=C2C=C1OCCN(CC)CC)NC3=CC(OC)=C(C=C3Cl)Cl

Molecular Formula

C22H26Cl2N4O3

Molecular Weight

465.37

References & Citations

[1]Barczyk A, et al. 4-Anilinoquinazoline Derivatives as the First Potent NOD1-RIPK2 Signaling Pathway Inhibitors at the Nanomolar Range. J Med Chem. 2024 Nov 14;67 (21) :19304-19322.