NOD1-RIPK2-IN-1
NOD1-RIPK2-IN-1 (Compound 37) is a NOD1-RIPK2 signaling pathway inhibitor with IC50 values of 42 nM and 1.52 nM for NOD1 and RIPK2, respectively. NOD1-RIPK2-IN-1 reduces the secretion of the pro-inflammatory cytokine IL-8 and can be used in the research of inflammation and immune-related diseases[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nod1-ripk2-in-1.html
Smiles
COC1=CC2=C(N=CN=C2C=C1OCCN(CC)CC)NC3=CC(OC)=C(C=C3Cl)Cl
Molecular Formula
C22H26Cl2N4O3
Molecular Weight
465.37
References & Citations
[1]Barczyk A, et al. 4-Anilinoquinazoline Derivatives as the First Potent NOD1-RIPK2 Signaling Pathway Inhibitors at the Nanomolar Range. J Med Chem. 2024 Nov 14;67 (21) :19304-19322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-8; NOD1; RIPK2
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