Icerguastat
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) . Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].
Product Specifications
CAS Number
951441-04-6
Product Name Alternative
Sephin1; IFB-088
UNSPSC
12352005
Hazard Statement
H301
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/icerguastat.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CC=CC=C1/C=N/NC(N)=N
Molecular Formula
C8H9ClN4
Molecular Weight
196.64
Precautions
H301
References & Citations
[1]Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142 (2) :344-361.|[2]Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348 (6231) :239-242.|[3]Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57 (5) :2206-2219.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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