PI3Kα-IN-19

PI3Kα-IN-19 (Compound 1) is a PI3Kα inhibitor with a targeted binding site at the p110α catalytic subunit. PI3Kα is one of the most common dysregulated kinases used in cancer research[1].

Product Specifications

CAS Number

[885692-56-8]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kα-in-19.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(C#N)=CN1)NC2=CC=C(C(CC3)CCN3C(C4=C[N+]([O-])=CC=C4)=O)C=C2C5=CCCCC5

Molecular Formula

C28H28N6O3

Molecular Weight

496.56

References & Citations

[1]Shafiq, Muhammad et al. “A deep learning-based theoretical protocol to identify potentially isoform-selective PI3Kα inhibitors.” Molecular diversity, 10.1007/s11030-023-10799-0. 2 Feb. 2024.