Skp2 Inhibitor C1

Skp2 Inhibitor C1 (SKPin C1) is an S-phase kinase-related protein 2 (Skp2) inhibitor with an inhibitory effect on metastatic melanoma cells. Skp2 Inhibitor C1 slows the cell cycle, inhibits cell proliferation, and triggers apoptosis[1].

Product Specifications

CAS Number

[432001-69-9]

Product Name Alternative

SKPin C1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Skp2-Inhibitor-C1.html

Purity

98.21

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

S=C(S/1)N(CC2=CN=CC=C2)C(C1=C\C(C=C(Br)C=C3)=C3OCC(O)=O)=O

Molecular Formula

C18H13BrN2O4S2

Molecular Weight

465.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang Y, et al. Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis. Braz J Med Biol Res. 2019;52 (5) :e8412. |[2]Li F, et al. Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. Behav Pharmacol. 2021 Feb 1;32 (1) :62-72.