Anti-Human/Rat HER2 (neu) Antibody (7.16.4)

Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is an anti-human and anti-rat HER2 IgG2a monoclonal antibody. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) reduces tumor cell proliferation by inhibiting the HER2 signaling pathway. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can activate CD8+ T cells. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can be used for research on cancer such as breast cancer[1][2].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

EGFR

Type

Inhibitory Antibodies

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-human-rat-her2-neu-antibody-7-16-4.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

[Anti-Human/RatHER2(neu)Antibody(7.16.4)]

Molecular Weight

(150 kDa)

References & Citations

[1]Liu S, et al. Pyrotinib and trastuzumab combination treatment synergistically overcomes HER2 dependency in HER2-positive breast cancer: insights from the PHILA trial. EBioMedicine. 2024 Nov;109:105379.|[2]Xu M, Du X, Liu M, Li S, Li X, Fu YX, Wang S. The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody. Protein Cell. 2012 Jun;3 (6) :441-9.