HMAO-B-IN-8

HMAO-B-IN-8 (Compound 23) is a hMAO-B, eeAChE, COX-2 and 5-LOX inhibitor, with IC50 values of 0.037 μM, 0.071 μM, 14.3 μM and 0.59 μM, respectively. hMAO-B-IN-8 can be used for the research of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; COX; Lipoxygenase; Monoamine Oxidase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hmao-b-in-8.html

Smiles

O=C(NC1=NC2=CC=C(O)C=C2S1)/C=C/C3=CC=C(C4=CC=CC=C4)C=C3

Molecular Formula

C22H16N2O2S

Molecular Weight

372.44

References & Citations

[1]Hussain F, et al. Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation. RSC Adv. 2024 Mar 28;14 (15) :10304-10321.