Alloxan (hydrate)

Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].

Product Specifications

CAS Number

[2244-11-3]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/alloxan-hydrate.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(C(O)=N1)C(O)=NC1=O.O

Molecular Formula

C4H4N2O5

Molecular Weight

160.08

Precautions

H302+H312+H332

References & Citations

[1]Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488 (2) :400-406.|[2]Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139 (1) :153-163. |[3]Rerup C, et al. Streptozotocin-and alloxan-diabetes in mice[J]. European Journal of Pharmacology, 1969, 7 (1) : 89-96.