Alloxan (hydrate)
Product Specifications
UNSPSC Description
Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].
Target Antigen
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/alloxan-hydrate.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Smiles
O=C(C(O)=N1)C(O)=NC1=O.O
Molecular Weight
160.08
References & Citations
[1]Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406.|[2]Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163. |[3]Rerup C, et al. Streptozotocin-and alloxan-diabetes in mice[J]. European Journal of Pharmacology, 1969, 7(1): 89-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W017227/Alloxan-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W017227/Alloxan-hydrate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2244-11-3
Available Sizes
Curated Selection
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