SIBA
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].
Product Specifications
CAS Number
35899-54-8
Product Name Alternative
5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSV; Nucleoside Antimetabolite/Analog; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SIBA.html
Purity
99.64
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSCC(C)C
Molecular Formula
C14H21N5O3S
Molecular Weight
339.41
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSV-1; Plasmodium
Available Sizes
Frequently Asked Questions
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