BMVC4
BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3 (T2AG3) 3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
Product Specifications
CAS Number
[868843-84-9]
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmvc4.html
Smiles
C[N+]1=CC(/C=C/C2=CC3=C(NC4=C3C=C(/C=C/C5=NC=C[N+](C)=C5)C=C4)C=C2)=NC=C1.[I-].[I-]
Molecular Formula
C26H23I2N5
Molecular Weight
659.30
References & Citations
[1]A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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