FR900098 (sodium)
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice[1][2].
Product Specifications
CAS Number
73226-73-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fr900098-sodium.html
Purity
99.7
Solubility
10 mM in DMSO
Smiles
O=C(C)N(CCCP(O)(O[Na])=O)O
Molecular Formula
C5H11NNaO5P
Molecular Weight
219.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Okuhara M, et al. Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. J Antibiot (Tokyo) . 1980 Jan;33 (1) :13-7.|[2]Wiesner J, et al. FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence. 2016 Aug 17;7 (6) :718-28.|[3]Verbrugghen T, et al. Synthesis and evaluation of α-halogenated analogues of 3- (acetylhydroxyamino) propylphosphonic acid (FR900098) as antimalarials[J]. Journal of medicinal chemistry, 2010, 53 (14) : 5342-5346.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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