FR900098 (sodium)

FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice[1][2].

Product Specifications

CAS Number

[73226-73-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fr900098-sodium.html

Purity

99.7

Solubility

10 mM in DMSO

Smiles

O=C(C)N(CCCP(O)(O[Na])=O)O

Molecular Formula

C5H11NNaO5P

Molecular Weight

219.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Okuhara M, et al. Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. J Antibiot (Tokyo) . 1980 Jan;33 (1) :13-7.|[2]Wiesner J, et al. FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence. 2016 Aug 17;7 (6) :718-28.|[3]Verbrugghen T, et al. Synthesis and evaluation of α-halogenated analogues of 3- (acetylhydroxyamino) propylphosphonic acid (FR900098) as antimalarials[J]. Journal of medicinal chemistry, 2010, 53 (14) : 5342-5346.