NSC622608
NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM[1].
Product Specifications
CAS Number
[2593254-90-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nsc622608.html
Purity
98.68
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 12.5 mg/mL (ultrasonic)
Smiles
CN(C)C1=N/C(SS1)=N/CC2=CC=CO2.Br
Molecular Formula
C9H12BrN3OS2
Molecular Weight
322.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Gabr MT, et al. Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA) . J Am Chem Soc. 2020 Sep 23;142 (38) :16194-16198.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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