SF1670

SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor[1].

Product Specifications

CAS Number

[345630-40-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Phosphatase; PTEN

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SF1670.html

Purity

98.57

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CC(C)(C)C(NC(C=C1C2=O)=CC=C1C3=C(C2=O)C=CC=C3)=O

Molecular Formula

C19H17NO3

Molecular Weight

307.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Li Y, et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117 (24) :6702-13.|[2]Montales MT, et al. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov;10 (6) :49.|[3]Amarjot Kaur Grewal, et al. Neuroprotective effect of pharmacological postconditioning on cerebral ischaemia-reperfusion-induced injury in mice. J Pharm Pharmacol. 2019 Jun;71 (6) :956-970.