SF1670
SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor[1].
Product Specifications
CAS Number
345630-40-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Phosphatase; PTEN
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SF1670.html
Purity
98.57
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC(C)(C)C(NC(C=C1C2=O)=CC=C1C3=C(C2=O)C=CC=C3)=O
Molecular Formula
C19H17NO3
Molecular Weight
307.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Y, et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117 (24) :6702-13.|[2]Montales MT, et al. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov;10 (6) :49.|[3]Amarjot Kaur Grewal, et al. Neuroprotective effect of pharmacological postconditioning on cerebral ischaemia-reperfusion-induced injury in mice. J Pharm Pharmacol. 2019 Jun;71 (6) :956-970.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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