Human Factor Xa

<strong>Human Factor Xa</strong>_x000D_ <strong>Catalog number:</strong> B2013656_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 0.8 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 46 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Human Factor Xa_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity N Engl J Med. 2015 Dec 17;373(25):2413-24._x000D_ 2: Newall F. Anti-factor Xa (anti-Xa) assay Methods Mol Biol. 2013;992:265-72._x000D_ 3: Nederpelt CJ, Naar L, Krijnen P, le Cessie S, Kaafarani HMA, Huisman MV, Velmahos GC, Schipper IB. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis Crit Care Med. 2021 Oct 1;49(10):e1025-e1036._x000D_ 4: Escolar G, Diaz-Ricart M, Arellano-Rodrigo E. Andexanet alfa: a recombinant mimetic of human factor Xa for the reversal of anticoagulant therapies Drugs Today (Barc). 2017 May;53(5):271-282._x000D_ 5: Becker RC. Factor Xa inhibitors: critical considerations for clinical development and testing J Thromb Thrombolysis. 2021 Aug;52(2):397-402._x000D_ 6: Thalji NK, Camire RM. Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding Curr Opin Hematol. 2017 Sep;24(5):453-459._x000D_ 7: Connors JM. Antidote for Factor Xa Anticoagulants N Engl J Med. 2015 Dec 17;373(25):2471-2._x000D_ 8: Sible AM, Nawarskas JJ. Andexanet Alfa for Reversing Factor Xa Inhibition Cardiol Rev. 2019 Mar/Apr;27(2):108-111._x000D_ 9: Monkovic DD, Tracy PB. Activation of human factor V by factor Xa and thrombin Biochemistry. 1990 Feb 6;29(5):1118-28._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28904343">10: Verhoef D, Visscher KM, Vosmeer CR, Cheung KL, Reitsma PH, Geerke DP, Bos MHA. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors Nat Commun. 2017 Sep 13;8(1):528. </a>_x000D_ _x000D_ <strong>Products Related to Human Factor Xa can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>