Urea-13C,15N2

Urea-13C,15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Product Specifications

CAS Number

[58069-83-3]

Product Name Alternative

Carbonyl diamide-13C,15N2

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/urea-13c-15n2.html

Purity

99.95

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

[15NH2][13C]([15NH2])=O

Molecular Formula

13CH4 15N2O

Molecular Weight

63.03

Precautions

H315, H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100 (9) :5142-7.|[3]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519 (11) :20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.|[4]Wang H, et al. Urea. Subcell Biochem. 201473:7-29.