NVP-DKY709
Product Specifications
UNSPSC Description
NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2[1][2].
Target Antigen
IKZF Family; Molecular Glues
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nvp-dky709.html
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1CCC(C(N1)=O)N2CC3=CC(C4CCN(CC4)CC5=CC=CC=C5)=CC=C3C2=O
Molecular Weight
417.50
References & Citations
[1]Simone BONAZZI, et al. Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives. WO2020128972 A1.|[2]Bonazzi S, et al. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol. 2023 Mar 16;30(3):235-247.e12.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144998/NVP-DKY709-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144998/NVP-DKY709-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2291360-73-9
Available Sizes
Curated Selection
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