10-Formyl-5,8-dideazafolic acid
10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor[1].
Product Specifications
CAS Number
[61038-31-1]
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10-formyl-5-8-dideazafolic-acid.html
Purity
96.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C=O)=CC=C2NC(N)=N1
Molecular Formula
C22H21N5O7
Molecular Weight
467.43
References & Citations
[1]Reddy MR, et, al. Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase. J. Am. Chem. Soc. 1992, 114, 26, 10117-10122.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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