10-Formyl-5,8-dideazafolic acid

10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor[1].

Product Specifications

CAS Number

[61038-31-1]

UNSPSC

12352005

Target

Thymidylate Synthase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/10-formyl-5-8-dideazafolic-acid.html

Purity

96.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=CC(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C=O)=CC=C2NC(N)=N1

Molecular Formula

C22H21N5O7

Molecular Weight

467.43

References & Citations

[1]Reddy MR, et, al. Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase. J. Am. Chem. Soc. 1992, 114, 26, 10117-10122.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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