AD-5584

AD-5584 is an ACSS2 inhibitor with blood-brain permeability. AD-5584 can significantly reduce lipid storage, reduce colony formation, and increase cell death. AD-5584 has antitumor activity[1].

Product Specifications

CAS Number

[2306525-79-9]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ad-5584.html

Purity

99.86

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=C(C(N2CCCCC2)C(N(C)CC3=NC4=CC(Cl)=CC=C4N3)=O)C=C1

Molecular Formula

C22H24ClFN4O

Molecular Weight

414.90

References & Citations

[1]Esquea E, et al. Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573073.