Isobutylparaben-d4

Isobutylparaben-d4 is the deuterium labeled Isobutylparaben. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics[1].

Product Specifications

CAS Number

[1219805-33-0]

Product Name Alternative

Isobutyl 4-hydroxybenzoate-d4

UNSPSC

12352005

Target

Apoptosis; Bacterial; Constitutive Androstane Receptor; PPAR; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Neurological Disease

Purity

98.5

Solubility

10 mM in DMSO

Smiles

CC(C)COC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O

Molecular Formula

C11H10D4O3

Molecular Weight

198.25

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chieri Fujino, et al. Comparative Study of the Effect of 17 Parabens on PXR-, CAR- And PPARα-mediated Transcriptional Activation. Food Chem Toxicol. 2019 Nov;133:110792.|[3]Fei Meng, et al. Isobutylparaben Negatively Affects Porcine Oocyte Maturation Through Increasing Oxidative Stress and Cytoskeletal Abnormalities. Environ Mol Mutagen. 2020 Apr61 (4) :433-444.