Numidargistat
Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Product Specifications
CAS Number
[2095732-06-0]
Product Name Alternative
CB-1158; INCB01158
UNSPSC
12352005
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CB-1158.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1
Molecular Formula
C11H22BN3O5
Molecular Weight
287.12
References & Citations
[1]Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5 (1) :101.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Biomed Pharmacother. 2022 Sep:153:113321.|Research Square Preprint. 2022 Mar.|The University of Chicago. 2023 Dec.|bioRxiv. 2024 Jul 31:2023.09.06.556606.|Cancer Cell. 2025 Feb 10;43 (2) :269-291.e19.|Cancer Lett. 2023 Jun 28:564:216208.|Cell Commun Signal. 2023 Sep 18;21 (1) :236.|J Physiol. 2020 Nov;598 (21) :4907-4925.|Patent. US20240307497A1.
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