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Ethacrynic acid (sodium)

Product Specifications

UNSPSC Description

Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

Target Antigen

Calcium Channel; Glutathione S-transferase; NF-κB; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ethacrynic-acid-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(O[Na])COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl

Molecular Weight

325.12

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B1640A/Ethacrynic-acid-sodium-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B1640A/

Clinical Information

Launched

CAS Number

6500-81-8

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