Ethacrynic acid (sodium)
Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs) . Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
Product Specifications
CAS Number
[6500-81-8]
Product Name Alternative
Etacrynic acid (sodium) ; Sodium etacrynate
UNSPSC
12352005
Target
Calcium Channel; Glutathione S-transferase; NF-κB; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ethacrynic-acid-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Na])COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl
Molecular Formula
C13H11Cl2NaO4
Molecular Weight
325.12
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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