PD 404182
PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2].
Product Specifications
CAS Number
72596-74-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Dimethylargininase (DDAH)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pd-404182.html
Purity
98.26
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N=C1SC2=CC=CC=C2C3=NCCCN13
Molecular Formula
C11H11N3S
Molecular Weight
217.29
Precautions
H315, H319, H335
References & Citations
[1]Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348 (1) : 69-76.|[2]Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58 (2) : 687-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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