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VU6008677

VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats[1].

Product Specifications

CAS Number

2170550-99-7

UNSPSC

12352211

Target

Cytochrome P450; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu6008677.html

Smiles

CC1=C(Cl)C(C)=NC2=C1C3=C(C(NC4CC4)=NC=N3)O2

Molecular Formula

C14H13ClN4O

Molecular Weight

288.73

References & Citations

[1]Capstick R A, et al. Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile[J]. ACS Medicinal Chemistry Letters, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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