VU6008677
VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats[1].
Product Specifications
CAS Number
2170550-99-7
UNSPSC
12352211
Target
Cytochrome P450; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu6008677.html
Smiles
CC1=C(Cl)C(C)=NC2=C1C3=C(C(NC4CC4)=NC=N3)O2
Molecular Formula
C14H13ClN4O
Molecular Weight
288.73
References & Citations
[1]Capstick R A, et al. Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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