CMPDA

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. IC50 value: 45.4 ± 4.2 nM/63.4 ± 5.6 nM (GluA2i/GluA2o) [1] Target: AMPAR modulator CMPDA was nearly equipotent at modulating the two isoforms of GluA2 receptors, whereas CMPDB displayed a modest preference for the flip splice variant. Similar to CX614, CMPDA slowed the rate of deactivation of GluA2o receptors approximately 2-fold but had no effect on GluA2i receptor deactivation [1].

Product Specifications

CAS Number

[380607-77-2]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CMPDA.html

Concentration

10mM

Purity

99.31

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(NCCC1=CC=C(CCNS(=O)(C(C)C)=O)C=C1)(C(C)C)=O

Molecular Formula

C16H28N2O4S2

Molecular Weight

376.53

References & Citations

[1]Timm DE, et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol Pharmacol. 2011 Aug;80 (2) :267-80.