VU0486321

VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs) . VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

Product Specifications

CAS Number

[1816301-67-3]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0486321.html

Purity

99.30

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=C2C(C(N(C2=O)C3=CC=C(C=C3Cl)NC(C4=C(C=CO4)C)=O)=O)=CC=C1

Molecular Formula

C20H12ClFN2O4

Molecular Weight

398.77

References & Citations

[1]Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs