(+) -JQ-1
(+) -JQ-1 (JQ1), a chemical probe, is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ) [1]. (+) -JQ-1 also activates autophagy[2].
Product Specifications
CAS Number
1268524-70-4
Product Name Alternative
JQ1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/__addition__-JQ-1.html
Purity
99.90
Solubility
DMSO : ≥ 45 mg/mL
Smiles
O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C
Molecular Formula
C23H25ClN4O2S
Molecular Weight
456.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468 (7327) :1067-73.|[2]Sakamaki JI, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and LysosomalFunction. Mol Cell. 2017 May 18;66 (4) :517-532.e9.|[3]Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150 (4) :673-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
BRD4
Available Sizes
Frequently Asked Questions
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