Pomalidomide-5-OH
Product Specifications
Product Name Alternative
5-Hydroxy pomalidomide; CC-17368
UNSPSC Description
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-5-oh.html
Purity
99.46
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3N)=O
Molecular Weight
289.24
References & Citations
[1]Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123324/Pomalidomide-5-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123324/Pomalidomide-5-OH-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1547162-41-3
Available Sizes
Curated Selection
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