Pomalidomide-5-OH

Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[1547162-41-3]

Product Name Alternative

5-Hydroxy pomalidomide; CC-17368

UNSPSC

12352005

Hazard Statement

H302, H312, H361

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-5-oh.html

Purity

99.46

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3N)=O

Molecular Formula

C13H11N3O5

Molecular Weight

289.24

Precautions

H302, H312, H361

References & Citations

[1]Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71 (2) :489-501.