EST64454 (maleate)
EST64454 maleate is a highly soluble σ1 receptor antagonist, demonstrating potent antinociceptive properties for pain treatment. EST64454 maleate exhibits excellent metabolic stability across various species and possesses an adequate pharmacokinetic profile in rodents. EST64454 maleate has been identified as a promising clinical candidate due to its favorable aqueous solubility and high permeability in Caco-2 cells.
Product Specifications
CAS Number
2088272-67-5
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/est64454-maleate.html
Smiles
OC(/C=C\C(O)=O)=O.CC(N(CC1)CCN1CCOCC2=NN(C3=CC(F)=C(C=C3)F)C=C2)=O
Molecular Formula
C22H26F2N4O6
Molecular Weight
480.46
References & Citations
[1]EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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