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11β-HSD1-IN-9

11β-HSD1-IN-9 (compound c4a) is a potent 11β-HSD1 inhibitor with IC50 values of 0.48 and 1.3 µM for human and murine 11β-HSD1, respectively. 11β-HSD1-IN-9 competitively interacts with rat 11β-HSD1. 11β-HSD1-IN-19 can be used in studies of obesity, hyperglycemia and cognitive impairment[1].

Product Specifications

CAS Number

88283-34-5

UNSPSC

12352005

Hazard Statement

H314

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/11β-hsd1-in-9.html

Solubility

10 mM in DMSO

Smiles

C1=C(C=CC(=C1)C(F)(F)F)C(=O)CC2=CN=CC=N2

Molecular Formula

C13H9F3N2O

Molecular Weight

266.22

Precautions

P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

References & Citations

[1]Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12 (1) :16268.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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