HX103
Product Specifications
UNSPSC Description
HX103 is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe. HX103 inhibits EGFR 19 del, EGFR L858R, EGFR wild type and EGFR T790M with IC50s of 1.3, 1.5, 4.0 and 977 nM, respectively. HX103 can be used for quantifying active-EGFR to predict agent sensitivity in NSCLC patients with EGFR-activating mutations[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hx103.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=C(C=C2N=CN=C(C2=C1)NC3=CC(Cl)=C(C=C3)F)OCCCNC4=CC=C(C5=NON=C45)S(=O)(N(C)C)=O
Molecular Weight
602.04
References & Citations
[1]Deng H, et al. A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations. Nat Commun. 2022 Nov 14;13(1):6944.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152098/HX103-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152098/HX103-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2566466-98-4
Available Sizes
Curated Selection
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