EGR-1-IN-2
EGR-1-IN-2 (compound 2) is an EGR-1 inhibitor with anti-inflammatory activity. EGR-1-IN-2 inhibits the formation of EGR-1-DNA complexes induced by TNF-α in HaCaT cells[1].
Product Specifications
CAS Number
152367-54-9
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/egr-1-in-2.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C2C=CC=CC2=C1C3=NNC(C3)C4=CC=C(C=C4)OC
Molecular Formula
C20H18N2O2
Molecular Weight
318.37
References & Citations
[1]Yoon H, et al. Pyrazolines inhibiting the activity of the early growth response-1 DNA-binding domain[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129952.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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