EGR-1-IN-2

EGR-1-IN-2 (compound 2) is an EGR-1 inhibitor with anti-inflammatory activity. EGR-1-IN-2 inhibits the formation of EGR-1-DNA complexes induced by TNF-α in HaCaT cells[1].

Product Specifications

CAS Number

[152367-54-9]

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/egr-1-in-2.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC=C2C=CC=CC2=C1C3=NNC(C3)C4=CC=C(C=C4)OC

Molecular Formula

C20H18N2O2

Molecular Weight

318.37

References & Citations

[1]Yoon H, et al. Pyrazolines inhibiting the activity of the early growth response-1 DNA-binding domain[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129952.