Biliatresone

Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model[1].

Product Specifications

CAS Number

[1801433-90-8]

UNSPSC

12352005

Hazard Statement

H300

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/biliatresone.html

Purity

99.48

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=C(C(C1=C(C=C2OCOC2=C1OC)OC)=O)C3=CC=CC=C3O

Molecular Formula

C18H16O6

Molecular Weight

328.32

Precautions

H300

References & Citations

[1]Kyung A Koo, et al. Biliatresone, a Reactive Natural Toxin From Dysphania Glomulifera and D. Littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone. Chem Res Toxicol. 2015 Aug 17;28 (8) :1519-21.|[2]Kristin Lorent, et al. Identification of a Plant Isoflavonoid That Causes Biliary Atresia. Sci Transl Med. 2015 May 6;7 (286) :286ra67.