ODN 1018
ODN 1018 (1018 ISS), an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′[1][2].
Product Specifications
CAS Number
[937402-51-2]
Product Name Alternative
1018 ISS
UNSPSC
12352208
Target
Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/odn-1018.html
Purity
99.28
Solubility
H2O : ≥ 100 mg/mL
Smiles
[DNA,d(P-thio)(T-G-A-C-T-G-T-G-A-A-C-G-T-T-C-G-A-G-A-T-G-A)]
Molecular Weight
7150.00
References & Citations
[1]Friedberg JW, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 Aug;146 (3) :282-91.|[2]Eng NF, et al. The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV™ review. Hum Vaccin Immunother. 2013 Aug;9 (8) :1661-72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Isoform
TLR9
Available Sizes
Curated Selection
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