NCGC00229600
NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR) . NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease[1].
Product Specifications
CAS Number
[1338824-20-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ncgc00229600.html
Purity
99.67
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC=CN=C2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5
Molecular Formula
C30H29N3O3
Molecular Weight
479.57
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96 (2) :548-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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