N-Desmethyl Zolmitriptan

N-Desmethyl Zolmitriptan (183C91; DZT) is the active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Zolmitriptan (HY-B0229) . N-Desmethyl Zolmitriptan (183C91; DZT) is an agonist of 5-HT1B receptors and induces constriction in isolated human cerebral arteries (EC50=100 nM) .

Product Specifications

CAS Number

[139264-35-0]

Product Name Alternative

183C91; DZT

UNSPSC

12352005

Hazard Statement

H302+H312+H332-H315-H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-desmethyl-zolmitriptan.html

Smiles

CNCCC1=CNC2=C1C=C(C[C@@H](CO3)NC3=O)C=C2

Molecular Formula

C15H19N3O2

Molecular Weight

273.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Patel, et al. Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: A sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study. Biomed. Chromatogr. 30 (3), 447-458 (2016) .