D-Leucine (Biotechnology Grade, High Purity)

<strong>D-Leucine</strong>_x000D_ <strong>Catalog number:</strong> B2010184_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 1 g_x000D_ <strong>pH:</strong> na_x000D_ <strong>Supplied as:</strong> Ready-to-use_x000D_ <strong>Appearance:</strong> White Powder_x000D_ <strong>Applications:</strong> multipurpose amino acid for protein synthesis, reagent stabilization, preparation of culture media and more._x000D_ <strong>Storage:</strong> Room temperature_x000D_ <strong>Keywords:</strong> (R)-2-Amino-4-methylpentanoic acid_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered on a 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Schoubben A, Vivani R, Paolantoni M, Perinelli DR, Gioiello A, Macchiarulo A,_x000D_ Ricci M. D-leucine microparticles as an excipient to improve the aerosolization_x000D_ performances of dry powders for inhalation. Eur J Pharm Sci. 2019 Mar_x000D_ 15;130:54-64._x000D_ _x000D_ 2: Koga R, Miyoshi Y, Sakaue H, Hamase K, Konno R. Mouse d-Amino-Acid Oxidase:_x000D_ Distribution and Physiological Substrates. Front Mol Biosci. 2017 Dec 4;4:82._x000D_ _x000D_ 3: Liska MG, Crowley MG, Tuazon JP, Borlongan CV. Neuroprotective and_x000D_ neuroregenerative potential of pharmacologically-induced hypothermia with_x000D_ D-alanine D-leucine enkephalin in brain injury. Neural Regen Res. 2018_x000D_ Dec;13(12):2029-2037._x000D_ _x000D_ 4: Sasabe J, Suzuki M. Emerging Role of D-Amino Acid Metabolism in the Innate_x000D_ Defense. Front Microbiol. 2018 May 9;9:933._x000D_ _x000D_ 5: Hasegawa H, Matsukawa T, Shinohara Y, Konno R, Hashimoto T. Role of renal_x000D_ D-amino-acid oxidase in pharmacokinetics of D-leucine. Am J Physiol Endocrinol_x000D_ Metab. 2004 Jul;287(1):E160-5._x000D_ _x000D_ 6: Zhang ZY, Ma N, Tao LJ, Gong XY, Ye WC, Wang L. Linear Peptides Containing_x000D_ d-Leucine with Neuroprotective Activities from the Leech <i>Whitmania pigra</i>_x000D_ Whitman. J Nat Prod. 2019 Aug 23;82(8):2349-2353._x000D_ _x000D_ 7: Hasegawa H, Matsukawa T, Shinohara Y, Hashimoto T. Kinetics of sequential_x000D_ metabolism from D-leucine to L-leucine via alpha-ketoisocaproic acid in rat._x000D_ Drug Metab Dispos. 2002 Dec;30(12):1436-40._x000D_ _x000D_ 8: Hamase K, Inoue T, Morikawa A, Konno R, Zaitsu K. Determination of free_x000D_ D-proline and D-leucine in the brains of mutant mice lacking D-amino acid_x000D_ oxidase activity. Anal Biochem. 2001 Nov 15;298(2):253-8._x000D_ _x000D_ 9: Sugimoto H, Kakehi M, Jinno F. Method development for the determination of D-_x000D_ and L-isomers of leucine in human plasma by high-performance liquid_x000D_ chromatography tandem mass spectrometry and its application to animal plasma_x000D_ samples. <a href="https://pubmed.ncbi.nlm.nih.gov/26345443/">Anal Bioanal Chem</a>. 2015 Oct;407(26):7889-98._x000D_ _x000D_ <strong>Products Related to D-Leucine </strong> <a>: Biochemical Buffers and Solutions</a>