Monoclonal Anti-B2M Antibody, Mouse IgG2b (BBM.1)

Monoclonal Anti-B2M Antibody, Mouse IgG2b (BBM.1) is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

Product Specifications

Background

Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system. B2M consists of two β sheets joined by a disulfide bond, which could form amyloid fibrils in some pathological conditions. Increasing evidence has indicated that B2M gene alterations in tumor cells may lower the efficacy of T-cell based immunotherapies by hampering MHC class I-mediated tumor antigen presentation and avoiding T cell recognition.

CAS Number

9007-83-4

Host

HEK293

Origin Species

Mouse

Target

B2M

Conjugation

Unconjugated

Tag

Mouse IgG2b | Mouse kappa

Applications

ELISA (Evaluation of levels of B2M protein) . Flow Cytometry (Evaluation of an epitope within the extracellular domain of human B2M protein) .

Stability

-20°C to -70°C for 24 months in lyophilized state; -70°C for 12 months after reconstitution. 2-8 °C for 12 months after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles.