3,5-Dihydroxybenzoic acid

3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active[1][2].

Product Specifications

CAS Number

[99-10-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Tyrosinase

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3,5-Dihydroxybenzoic_acid.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 60 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(O)=CC(O)=C1

Molecular Formula

C7H6O4

Molecular Weight

154.12

Precautions

H315, H319

References & Citations

[1]Liu C, et al., 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012 Jun;341 (3) :794-801.|[2]Kobayashi T, et al., 3,5-Dihydroxybenzoic Acid as a Potent Inhibitor of Tyrosine Phenol-Lyase Decreases Fecal Phenol Levels in Mice. J Med Chem. 2025 Apr 2.