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Apomine

Product Specifications

UNSPSC Description

Apomine (SR-45023A) is an antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. In addition, Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer[1].

Target Antigen

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apomine.html

Purity

99.67

Solubility

DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC(P(OC(C)C)(OC(C)C)=O)P(OC(C)C)(OC(C)C)=O)=C1

Molecular Weight

562.66

References & Citations

[1]Kuehl PJ, et al. Preformulation, formulation, and in vivo efficacy of topically applied apomine. Int J Pharm. 2009;382(1-2):104-110.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-19671/Apomine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19671/Apomine-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

126411-13-0

Available Sizes

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